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KMID : 0366220090440040304
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Korean Journal of Hematology
2009 Volume.44 No. 4 p.304 ~ p.309
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Oral Beclomethasone Dipropionate for the Treatment of Steroid-refractory Gastrointestinal Acute Graft-versus-host Disease
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Lee Sung-Eun
Lee Seok
Cho Byung-Sik
Eom Ki-Seong
Kim Yoo-Jin
Kim Hee-Je
Min Chang-Ki
Cho Seok-Goo
Kim Dong-Wook
Lee Jong-Wook
Min Woo-Sung
Park Chong-Won
Kim Chun-Choo
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Abstract
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Acute graft-versus-host disease (GVHD) is one of the most severe complications following allogeneic stem cell transplantation (SCT), and involvement of the gut has been associated with increased mortality and a poorer response to high-dose systemic corticosteroids. For over a decade, oral beclomethasone dipropionate (BDP) has been studied in the treatment of acute gastrointestinal GVHD, as a monotherapy, or in combination with systemic corticosteroids. Here we report, for the first time in Korea, the efficacy of oral BDP (8 mg/day for 25 days) in 3 adults with acute lymphoblastic leukemia who developed steroid-refractory gastrointestinal GVHD (grade III) after myeloablative conditioning SCT (1 matched sibling transplant, 2 matched unrelated transplants). All patients responded completely to oral BDP treatment. Oral BDP is safe and effective for the control of steroid-refractory acute gastrointestinal GVHD. (Korean J Hematol 2009;44:304-309.)
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KEYWORD
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Oral beclomethasone dipropionate, Allogeneic stem cell transplantation, Gastrointestinal acute graft-versus-host disease
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